October is Breast Cancer Awareness Month. Around the world, pink ribbons symbolize solidarity and hope. But for us at LYF, awareness is only the first step. True empowerment comes when awareness leads to action — and when prevention protects not just one woman, but her entire family.

Breast Cancer by the Numbers

• 1 in 8 women will be diagnosed with breast cancer during her lifetime.
• Early detection makes a huge difference: localized breast cancer has a 5-year survival rate of 99%, compared with 29% when diagnosed late.
• Genetics plays a major role: inherited mutations in BRCA1, BRCA2, TP53, PALB2, and other genes dramatically increase lifetime risk.

From Genes to Generations

Genetics doesn’t just affect one person. A single test can change the health trajectory of an entire family.

- A woman who carries a BRCA1 mutation may choose enhanced MRI surveillance from ager 25-30 years and risk reducing surgery of the breasts, reducing breast cnacer risk by up to 80%.
- Her daughter, tested at 25, can plan her life with knowledge — screening earlier, preserving fertility, and considering age appropriate preventive surgical options before cancer ever develops.
- Siblings, cousins, and all eligible family members can be tested and protected.

This is what we mean when we say: prevention spans generations.

The Latest Science (2025 Updates)

Genetic clarity: In 2025, scientists used CRISPR-Cas9 to re-classify ~7,000 BRCA2 sequence variants, clarifying which are harmful and require medical and/or surgical action and reducing uncertainty in the genetic results by reducing the number of variants of uncertain significance - VUS.

Advanced imaging: A UK trial showed contrast-enhanced mammography detects nearly 16 invasive cancers per 1,000 exams — especially valuable for women with dense breast tissue in regions where breast MRI is not readily available.

Biomarkers: The U.S. National Cancer Institute identified stromal disruption in breast tissue as a marker of future aggressive cancers, even when biopsy results seem benign.

AI risk tools: New AI models using 3D mammography predict 5-year breast cancer risk with accuracy close to clinical gold standards.

Lifestyle matters: A 2025 Brazilian study found that women following nutrition and activity guidelines (more fiber, fewer sugary drinks) had significantly better 10-year survival after breast cancer.

LYF’s Preventive Approach

At LYF, we believe in transforming these scientific advances into everyday healthcare:

1. Genetic Screening – our 180 actionable gene panel identifies clinically meaningful health risks.
2. Family Cascade Testing – one test safeguards daughters, sisters, and mothers.
3. Personalized Imaging – mammography, MRI, or contrast-enhanced imaging chosen based on your biology.
4. Lifestyle Medicine – nutrition, physical activity, sleep, and stress management tailored to help in risk reduction.
5. Continuous Support – from nurse visits to AI-driven reports, your plan evolves as you do.

A Story of Prevention

A 42-year-old mother is diagnosed with breast cancer. Genetic testing reveals a BRCA1 mutation. She is offered risk reducing removal of her ovaries and fallopian tubes to minimize her risk for developing ovarian cancer. Her 25-year-old daughter also tests positive — but unlike her mother, she starts semiannual breast MRI screening at 25 years of age. She plans risk-reducing surgery after childbearing at 37. The result? She may never be diagnosed with breast cancer.

One test protected two generations — and potentially saved a third.

This October, let’s go beyond pink ribbons.

- Know your family history.
- Ask about genetic testing.
- Don’t delay screenings — mammograms and MRIs save lives.
- Adopt prevention as a lifestyle.

At LYF, we honor Breast Cancer Awareness Month by helping families move from genes to generations, turning awareness into action, and lifespan into healthspan.

A Personal Note

Prof. Eitan Friedman, MD, PhD — Chief Medical Officer, LYF

"As a physician and geneticist, I have seen far too many families discover cancer only after it was too late. But I have also witnessed how a single genetic test can prevent tragedy — not just for one woman, but for her daughters and granddaughters. Prevention is not a slogan; it is a responsibility.

This Breast Cancer Awareness Month, I urge you to look beyond awareness and into action. Know your family history. Ask about genetic testing. Share knowledge with your loved ones. Together, we can change the story of breast cancer — from fear to prevention, from genes to generations."